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Before Taking This Medicine
If Zoloft is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zoloft with the foll
owing:
- Cimetidine (Tagamet)
- Diazepam (Valium)
- Digitoxin (Crystodigin)
- Flecainide (Tambocor)
- Lithium (Eskalith, Lithobid)
- MAO inhibitor drugs such as the antid
epressants Nardil and Parnate
- Other serotonin-boosting drugs such as Paxil and Prozac
- Other antidepressants such as Elavil and Serzone
- Over-the-counter drugs such as cold remedies
- Propafenone (Rythmol)
- Sumatriptan (Imitrex)
- Tolbutamide (Orinase)
- Warfarin (Coumadin)
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Symptoms of overdose
Establish and maintain an airway, insure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage, and should be con
sidered in treating overdose.
Cardiac and vital signs monitoring are recommended along with general symptomatic and supportive measures.
There are no specific antidotes for sertral
ine.
Due to the large volume of distribution of sertraline, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit.
In managing overdose,
the possibility of multiple drug involvement must be considered.
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How should this medicine be used?
Zoloft concentrate must be diluted before use. Immediately before taking it, use the provided dropper to remove the amount of concentrate your doctor has directed you to take. Mix the concentrate with
4 ounces (1/2 cup) of water, ginger ale, lemon or lime soda, lemonade, or orange juice. Drink immediately. Do not mix the concentrate with any liquids other than the ones listed.
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Side Effects
Side effects from Zoloft are common:
- upset stomach
- drowsiness
- weakness or tiredness
- excitement or anxiety
- insomnia
- nightmares
- dry mouth
- ski
n more sensitive to sunlight than usual
- changes in appetite or weight
Tell your doctor if any of these symptoms are severe or do not go away:
- constipation
- difficult
y urinating
- frequent urination
- blurred vision
- changes in sex drive or ability
- excessive sweating
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Special Wanring
In clinical development programs, sertraline has been evaluated in 1902 subjects with depression. The most commonly observed adverse events associated with the use of sertraline were: gastrointestinal
complaints, including nausea, diarrhea/loose stools and dyspepsia; male sexual dysfunction (primarily ejaculatory delay); insomnia and somnolence; tremor; increased sweating and dry mouth; and dizzin
ess. In the fixed dose placebo controlled study, the overall incidence of side effects was dose related with a majority occurring in the patients treated with 200 mg dose.
The discontinuatio
n rate due to adverse events was 15% in 2710 subjects who received sertraline in premarketing multiple dose clinical trials.
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What is this medicine
In addition, Zoloft is used in the treatment of obsessive-compulsive disorder--symptoms of which include unwanted thoughts that won't go away and an irresistible urge to keep repeating certain actions
, such as hand-washing or counting. It is also prescribed for the treatment of panic disorder (unexpected attacks of overwhelming anxiety, accompanied by fear of their return), and for posttraumatic s
tress disorder (re-experiencing a dangerous or life-threatening event through intrusive thoughts, flashbacks, and intense psychological distress).
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