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Before Taking This Medicine
Older adults¡XMany medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effec
s or problems in older people. In studies done to date that included elderly people, Prozac did not cause different side effects or problems in older people than it did in younger adults.
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What is this Drug
Prozac is used to treat mental depression. It is also used to treat obsessive-compulsive disorder, bulimia nervosa, and premenstrual dysphoric disorder.
Prozac also may be used for other cond
itions as determined by your doctor.
Prozac belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines are thought to work by increasing the act
ivity of a chemical called serotonin in the brain.
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What side effects may occur?
Side effects from Prozac are common:
- upset stomach
- drowsiness
- weakness or tiredness
- excitement or anxiety
- insomnia
- nightmares
- dry mouth
- ski
n more sensitive to sunlight than usual
- changes in appetite or weight
Tell your doctor if any of these symptoms are severe or do not go away:
- constipation
- difficult
y urinating
- frequent urination
- blurred vision
- changes in sex drive or ability
- excessive sweating
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Adverse Effects
Serious Adverse Reactions: - Suicidal thoughts and acts are far more common among depressed patients than in the general population. It is estimated that suicide is 22 to 36 times more prevalent in de
pressed persons than in the general population. A comprehensive meta-analysis of pooled data from 17 double blind clinical trials in patients with major depressive disorder compared fluoxetine (n=1765
) with a tricyclic antidepressant (n=731) or placebo (n=569), or both. The pooled incidence of emergence of substantial suicidal ideation was 1.2% for fluoxetine, 2.6% for placebo, and 3.6% for tricyc
lic antidepressants.
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Drug Interactions
General Anesthetics: - Since little is known about the interaction between fluoxetine and general anesthetics, fluoxetine should be discontinued for as long as clinically possible prior to elective su
rgery.
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Warning
Pregnancy and Lactation: - Safe use of fluoxetine during pregnancy and lactation has not been established. Therefore, it should not be administered to women of childbearing potential or nursing mother
s unless, in the opinion of the treating physician, the expected benefits to the patient markedly outweigh the possible hazards to the child or fetus. In 1 breast milk sample, the concentration of flu
oxetine plus norfluoxetine was 70.4 ng/mL. The concentration in the mother's plasma was 295 ng/mL. No adverse effects on the infant were reported.
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